Do you know how the many nutrients we consume each day are actually used in the body? In truth, for a surprising number of them―including vitamin K and the nucleotide GTP―their metabolic pathways remain only partly understood. Our laboratory seeks to elucidate how diverse nutrients are processed in vivo and how they affect disease, using biochemical and molecular biology approaches. Our goal is to inform prevention and treatment of age-associated conditions such as Alzheimer’s disease, osteoporosis, and cancers, thereby prolonging the period of health before illness and extending healthspan. We also collaborate with industry partners to translate our findings into real-world applications, including cosmetic ingredients and diagnostic markers, with the broader aim of advancing the value of nutrients and promoting longer, healthier lives.